MARCH 23:  If you currently have FTS ultrasound booked with us, we will be in touch with you shortly to review your options during the COVID-19 pandemic.

First Trimester Screening (FTS) is a non-invasive method of assessing early fetal growth, anatomy, and the chances of certain chromosomal differences. It is performed through ultrasound and bloodwork at 11-14 weeks gestation.

PCRM is excited to announce that, as of 2020, our FTS program also includes screening for pre-eclampsia (PE). Pre-eclampsia is a multi-system disorder that affects 2-5% of pregnant women, and is a leading cause of maternal and fetal morbidity and mortality. It is characterized by high blood pressure and signs of damage to organ systems, usually the liver and kidneys. PE screening details are provided below.

First Trimester Screening was developed largely through the work of the Fetal Medicine Centre, London, UK and the pioneering ideas of Professor Kypros Nicolaides. Since 1990, Nicolaides has been targeting research towards the early detection of genetic syndromes, in methods which involve examining the baby at an early stage in its development (the end of the first trimester, or 11-14 weeks). Since its inception, new discoveries have been added to the original finding of Nuchal Translucency (NT).

The most common chromosome differences include trisomy 21 (Down syndrome), trisomy 18 (Edward syndrome), and trisomy 13 (Patau syndrome). All of these disorders affect the baby’s development and range in severity from mild to severe. In the process of FTS, 6 markers are used to statistically assess the chance of one of the syndromes. These markers all fall under a quality review program through the Fetal Medicine Foundation, to ensure reproducibility, and global uniformity of testing. The markers include:

NT – Nuchal Translucency
Blood work for PAPP-A and free-beta HCG (proteins in the mother’s blood)
NB – Nasal Bone
FHR – Fetal Heart Rate
DV – Ductus Venosus Flow

The combination of all six, in conjunction with maternal age, provides a 96% likelihood of detection, with a 3% chance of a falsely positive result. Full fetal anatomy is also reviewed for major defects.

PE screening uses a combination of maternal risk factors, blood pressure measurements, ultrasound and blood test markers to predict the risk of pre-term PE in a pregnancy. Women identified at high risk for PE are recommended to take prophylactic aspirin to reduce their risks. PE screening includes:

MAP – Mean Arterial Pressure (mother’s blood pressure)
PlGF – Placental Growth Factor (protein in mother’s blood)
PAPP-A – Pregnancy-associated plasma protein A (protein in mother’s blood)
UTPI – Uterine Artery Pulsatility Index

There are two versions of early genetic screening in pregnancy – NIPT (which is based on cell-free fetal DNA) and FTS. Both are integrated, along with PE screening, in the comprehensive screening package called TriO (new link).

PCRM offers several options for prenatal screening, including first trimester screening (FTS), non-invasive prenatal testing (NIPT), pre-eclampsia screening (PE), and a combination of the three (TriO). The following table summarizes what each prenatal screening option offers.

TriO

NIPT only FTS & PE only
Singleton Twins Standard NIPT (singleton or twins)

Standard NIPT + 8 Microdeletion Syndromes (singleton only)

First Trimester Screening

Abdominal ultrasound: viability, growth, early anatomy, markers of chromosome differences (NT, FHR, DV, NB)*

Maternal serum: PAPP-A and hCG

 

Pre-Eclampsia Screening

(maternal blood pressure, serum PlGF, PAPP-A, history questionnaire)

 

NIPT: Chromosome differences -Trisomy 21 (Down syndrome), Trisomy 18, Trisomy 13

 

NIPT:  Sex chromosome differences (X, XXY, XXX, XYY)

 

(optional)

Not available (singleton only)

NIPT: Fetal sex(es)

(optional)

(optional)

NIPT:

Microdeletion Syndromes

6 (optional)

22q11.2 del syndrome
Cri-du-chat syndrome

1p36 deletion syndrome

Prader-Willi syndrome

Angelman syndrome

Wolf-Hirschhorn syndrome

Not available  

8

 

22q11.2 del syndrome
Cri-du-chat syndrome

1p36 deletion syndrome

Prader-Willi syndrome

Angelman syndrome

Wolf-Hirschhorn syndrome
Jacobsen syndrome**
Langer-Giedion syndrome**

 

Cost (CAD- no tax)

$1000

$1250*** $650 $950

$650

*NT = nuchal translucency, FHR = fetal heart rate, DV = ductus venosus flow, NB = nasal bone

**All microdeletion syndromes are rare, these two syndromes are very rare

***If you want to know the sex of both babies, the cost is $1250. If not, the cost is $1000.